SCIENCE of SmartSunscreens

Photodamage Occurs Every Day.

Every day, even in cloud cover, ultraviolet (UV) radiation assaults exposed skin. UV-induced damage is cumulative; its wounding effects on the skin's DNA account for nearly all visible signs of aging and contribute to 90% of non-melanoma skin cancers.¹

• UVB radiation (burning rays) inflicts damage to the skin's superficial epidermal layers.
• UVA radiation (aging rays) penetrates skin more deeply, damaging cells where skin cancers originate.

The Effects of UV Exposure on DNA.

DNA controls the genetic program of the skin and the greatest threat to it comes from the sun. DNA absorbs both UVA and UVB radiation, undergoing a photochemical reaction that produces cyclobutane pyrimidine dimers and other photoproducts that degrade cellular integrity.

Each incidence of sun exposure triggers a complex response sequence in the cells, whether or not sunburn forms. After decades of repeated damage and response cycles, the skin eventually loses the ability to repair itself.

The consequences of unrepaired DNA damage are enormous. In the early stages, DNA damage appears as texture and tone loss, wrinkle formation, and hyperpigmentation; in the end stages, actinic keratoses and skin cancers result.

Neova combines advanced DNA repair with potent antioxidant defense and broad-spectrum UVA/ UVB filters to create truly complete daily photoprotection.

DNA Damage Control™ Sunscreens Repair + Protect.

• Proprietary DNA repair enzymes paired with powerful antioxidants disrupt the photochemical cascade to arrest and correct skin damage.
• Zinc oxide and titanium dioxide offer high-performance physical UVA/UVB protection.
• Octinoxate and octisalate filter UVB rays.

Breakthrough DNA Repair Therapy.

DNA Damage Control sunscreens defend against UV insults with the newest, most powerful therapy: activation of the skin's DNA repair process delivered through liposome-encapsulated DNA repair enzymes deep into the epidermis—the site of DNA injury. Clinical studies document the role of these enzymes in reparation and protection, proving the consequences of UV-induced damage can be significantly reduced.

• Photolysomes. Liposome-encapsulated DNA repair enzyme derived from plankton. Unique in the ability to undo DNA damage in cells and prevent UV-induced cell death, Photolysomes hyper-efficiently defend against high doses of solar UV.⁴
• Endosomes. Liposome-encapsulated extract from an extremely UV-resistant marine microbe. The extract contains UV-endonuclease, an enzyme that intensifies the skin's ability to repair solar DNA damage, speeding recovery reaction and reducing the appearance of post-sunburn peeling.⁵

1. Skin Care Foundation, www.skincancer.org, Accessed 4/19/11.

2,3. Stege H, Roza L, Vink AA , et al. Enzyme plus light therapy to repair DNA damage in ultraviolet-B-irradiated human skin. Proc Natl Acad Sci. 2000; 97(4).

4. Kulms D, Poppelmann B, Yarosh D, et al. Nuclear and cell membrane effects contribute independently to the induction of apoptosis in human cells exposed to UVB radiation. Proc Natl Acad Sci. 1999;96:7974-7979.

5. Yarosh DB, Kibitel J, O'Connor A, et al. DNA repair liposomes in animutagenesis. J Environ Pathol Toxicol Oncol. 1997;16:287-292.